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Author: search.filters.author.Gregory MertzSubject: search.filters.subject.hantavirus infection

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      27Scopus© Citations 4
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    Mother-to-Child Transmission of Andes Virus through Breast Milk, Chile1
    (2020)
    Marcela Ferrés
    ;
    Constanza Martínez-Valdebenito
    ;
    Jenniffer Angulo
    ;
    Carolina Henríquez
    ;
    Jorge Vera-Otárola
    Scopus© Citations 17  4
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    A Single-Nucleotide Polymorphism of αVβ3 Integrin Is Associated with the Andes Virus Infection Susceptibility
    (2019)
    Constanza Martínez-Valdebenito
    ;
    Jenniffer Angulo
    ;
    Nicole Le Corre
    ;
    Claudia Marco
    ;
    VIAL COX, MARIA CECILIA  
    <jats:p>The Andes Orthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as “TT” (coding leucine) and “CC” (coding proline), respectively. TT was present at a rate of 89.2% (66/74) among the first cohort of ANDV cases and at 60% (63/105) among exposed close-household contacts, who remained uninfected (p &lt; 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4% of the exposed close-household contacts who remained uninfected. Logistic regression modeling for risk of infection had an OR of 6.2–12.6 (p &lt; 0.05) in the presence of TT and well-known ANDV risk activities. Moreover, an OR of 7.3 was obtained when the TT condition was analyzed for two groups exposed to the same environmental risk. Host genetic background was found to have an important role in ANDV infection susceptibility, in the studied population.</jats:p>
    Scopus© Citations 12  4
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      25Scopus© Citations 5
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    Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome
    (2019)
    LOPEZ HERNANDEZ, RENE RAMON  
    ;
    Mario Calvo
    ;
    VIAL COX, MARIA CECILIA  
    ;
    Marcela Ferrés
    ;
    GRAF SANTOS, JERÓNIMO  
    <jats:p>Background: Hantavirus cardiopulmonary syndrome (HCPS) has a mortality up to 35–40% and its treatment is mainly supportive. A variable to predict progression from mild to severe disease is unavailable. This study was performed in patients with documented infection by Andes orthohantavirus, and the aim was to find a simple variable to predict progression to moderate/severe HCPS in patients with mild disease at admission. Methods: We performed a retrospective analysis of 175 patients between 2001 and 2018. Patients were categorized into mild, moderate, and severe disease according to organ failure and advanced support need at hospital admission (e.g., mechanical ventilation, vasopressors). Progression to moderate/severe disease was defined accordingly. Clinical and laboratory variables associated with progression were explored. Results: Forty patients with mild disease were identified; 14 of them progressed to moderate/severe disease. Only platelet count was different between those who progressed versus those that did not (37 (34–58) vs. 83 (64–177) K/mm3, p &lt; 0.001). A ROC curve analysis showed an AUC = 0.889 (0.78–1.0) p &lt; 0.001, with a platelet count greater than 115K /mm3 ruling out progression to moderate/severe disease. Conclusions: In patients with mild disease at presentation, platelet count could help to define priority of evacuation to tertiary care centers.</jats:p>
    Scopus© Citations 10  4