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Proteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality
(2021)
LOPEZ HERNANDEZ, RENE RAMON
;
Gregory Mertz
;
GRAF SANTOS, JERÓNIMO
;
Mauricio Espinoza
;
Marcela Ferrés
27Scopus© Citations 4
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Mother-to-Child Transmission of Andes Virus through Breast Milk, Chile1
(2020)
Marcela Ferrés
;
Constanza Martínez-Valdebenito
;
Jenniffer Angulo
;
Carolina Henríquez
;
Jorge Vera-Otárola
Scopus© Citations 17 4
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Knowledge, attitudes, and practices regarding hantavirus disease and acceptance of a vaccine trial in rural communities of southern Chile
(2017)
Francisca Valdivieso
;
GONZALEZ WIEDMAIER, CLAUDIA MARTA
;
Manuel Najera
;
Analia Cuiza
;
OLEA NORMANDIN, ANDREA MARIA
1Scopus© Citations 14
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A Single-Nucleotide Polymorphism of αVβ3 Integrin Is Associated with the Andes Virus Infection Susceptibility
(2019)
Constanza Martínez-Valdebenito
;
Jenniffer Angulo
;
Nicole Le Corre
;
Claudia Marco
;
VIAL COX, MARIA CECILIA
<jats:p>The Andes Orthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as “TT” (coding leucine) and “CC” (coding proline), respectively. TT was present at a rate of 89.2% (66/74) among the first cohort of ANDV cases and at 60% (63/105) among exposed close-household contacts, who remained uninfected (p < 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4% of the exposed close-household contacts who remained uninfected. Logistic regression modeling for risk of infection had an OR of 6.2–12.6 (p < 0.05) in the presence of TT and well-known ANDV risk activities. Moreover, an OR of 7.3 was obtained when the TT condition was analyzed for two groups exposed to the same environmental risk. Host genetic background was found to have an important role in ANDV infection susceptibility, in the studied population.</jats:p>
Scopus© Citations 12 4
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Sociodemographic risk factors of hantavirus cardiopulmonary syndrome ^[Factores de riesgo socio-demográficos del síndrome]
(2019)
VIAL COX, MARIA CECILIA
;
Francisca Valdivieso R.
;
Analía Cuiza V.
;
Iris Delgado B.
;
Grazielle Ribeiro E.
25Scopus© Citations 5

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