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Author: search.filters.author.Gonzalo LabarcaSubject: search.filters.subject.endosonography

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    Item type:Publication,
    Minimally Invasive Methods for Staging in Lung Cancer: Systematic Review and Meta-Analysis
    (2016)
    Gonzalo Labarca
    ;
    Carlos Aravena
    ;
    Francisco Ortega
    ;
    Alex Arenas
    ;
    Adnan Majid
    <jats:p><jats:italic>Introduction</jats:italic>. Endobronchial ultrasound (EBUS) is a procedure that provides access to the mediastinal staging; however, EBUS cannot be used to stage all of the nodes in the mediastinum. In these cases, endoscopic ultrasound (EUS) is used for complete staging.<jats:italic>Objective</jats:italic>. To provide a synthesis of the evidence on the diagnostic performance of EBUS + EUS in patients undergoing mediastinal staging.<jats:italic>Methods</jats:italic>. Systematic review and meta-analysis to evaluate the diagnostic yield of EBUS + EUS compared with surgical staging. Two researchers performed the literature search, quality assessments, data extractions, and analyses. We produced a meta-analysis including sensitivity, specificity, and likelihood ratio analysis.<jats:italic>Results</jats:italic>. Twelve primary studies (1515 patients) were included; two were randomized controlled trials (RCTs) and ten were prospective trials. The pooled sensitivity for combined EBUS + EUS was 87% (CI 84–89%) and the specificity was 99% (CI 98–100%). For EBUS + EUS performed with a single bronchoscope group, the sensitivity improved to 88% (CI 83.1–91.4%) and specificity improved to 100% (CI 99-100%).<jats:italic>Conclusion</jats:italic>. EBUS + EUS is a highly accurate and safe procedure. The combined procedure should be considered in selected patients with lymphadenopathy noted at stations that are not traditionally accessible with conventional EBUS.</jats:p>
      7Scopus© Citations 22
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      12Scopus© Citations 1