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    The “when” matters: Evidence from memory markers in the clinical continuum of Alzheimer’s disease.
    (2023)
    Gonzalo Forno
    ;
    Mario A. Parra
    ;
    Daniela Thumala
    ;
    Roque Villagra
    ;
    Mauricio Cerda
      6Scopus© Citations 5
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    Moral Emotions and Their Brain Structural Correlates Across Neurodegenerative Disorders
    (2023)
    Sandra Baez
    ;
    Catalina Trujillo-Llano
    ;
    Leonardo Cruz de Souza
    ;
    Patricia Lillo
    ;
    Gonzalo Forno
    <jats:p>Background: Although social cognition is compromised in patients with neurodegenerative disorders such as behavioral variant frontotemporal dementia (bvFTD) and Alzheimer’s disease (AD), research on moral emotions and their neural correlates in these populations is scarce. No previous study has explored the utility of moral emotions, compared to and in combination with classical general cognitive state tools, to discriminate bvFTD from AD patients. Objective: To examine self-conscious (guilt and embarrassment) and other-oriented (pity and indignation) moral emotions, their subjective experience, and their structural brain underpinnings in bvFTD (n = 31) and AD (n = 30) patients, compared to healthy controls (n = 37). We also explored the potential utility of moral emotions measures to discriminate bvFTD from AD. Methods: We used a modified version of the Moral Sentiment Task measuring the participants’ accuracy scores and their emotional subjective experiences. Results: bvFTD patients exhibited greater impairments in self-conscious and other-oriented moral emotions as compared with AD patients and healthy controls. Moral emotions combined with general cognitive state tools emerged as useful measures to discriminate bvFTD from AD patients. In bvFTD patients, lower moral emotions scores were associated with lower gray matter volumes in caudate nucleus and inferior and middle temporal gyri. In AD, these scores were associated with lower gray matter volumes in superior and middle frontal gyri, middle temporal gyrus, inferior parietal lobule and supramarginal gyrus. Conclusion: These findings contribute to a better understanding of moral emotion deficits across neurodegenerative disorders, highlighting the potential benefits of integrating this domain into the clinical assessment.</jats:p>
      24Scopus© Citations 3
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    Automated text‐level semantic markers of Alzheimer's disease
    (2022)
    Camila Sanz
    ;
    Facundo Carrillo
    ;
    Andrea Slachevsky  
    ;
    Gonzalo Forno
    ;
    Maria Luisa Gorno Tempini
    Scopus© Citations 30  1
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    Multimodal neurocognitive markers of naturalistic discourse typify diverse neurodegenerative diseases
    (2021)
    Agustina Birba
    ;
    Sol Fittipaldi
    ;
    Judith C Cediel Escobar
    ;
    Cecilia Gonzalez Campo
    ;
    Agustina Legaz
    <jats:title>Abstract</jats:title> <jats:p>Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial events, in Parkinson’s disease (PD) and behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer’s disease patients and healthy controls. Text-specific correlates were evaluated via voxel-based morphometry, spatial (fMRI), and temporal (hd-EEG) functional connectivity. PD patients presented action–text deficits related to the volume of action–observation regions, connectivity across motor-related and multimodal-semantic hubs, and frontal hd-EEG hypoconnectivity. BvFTD patients exhibited social–text deficits, associated with atrophy and spatial connectivity patterns along social-network hubs, alongside right frontotemporal hd-EEG hypoconnectivity. Alzheimer’s disease patients showed impairments in all stories, widespread atrophy and spatial connectivity patterns, and heightened occipitotemporal hd-EEG connectivity. Our framework revealed disease-specific signatures across behavioral, neuroanatomical, and neurofunctional dimensions, highlighting the sensitivity and specificity of a single naturalistic task. This investigation opens a translational agenda combining ecological approaches and multimodal cognitive neuroscience for the study of neurodegeneration.</jats:p>
      2Scopus© Citations 39
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    Scopus© Citations 18  1