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Author: search.filters.author.Francisca ValdiviesoSubject: search.filters.subject.controlled study

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    Item type:Publication,
    Performance of the VITEK® MS system for the identification of filamentous fungi in a microbiological laboratory in Chile
    (Public Library of Science (PLoS), 2024-12-23)
    PORTE TORRE, LORENA ISABEL  
    ;
    Rodrigo Cruz
    ;
    Pérez Villa, Inia
    ;
    Carmen Varela
    ;
    Cristina Díaz
    <jats:p>Filamentous fungi are an emergent cause of severe infections in immunocompromised patients. Timely and accurate identification is crucial to initiate appropriate therapy. Traditional identification methods are time-consuming, labor-intensive, and operator-dependent. Matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) mass spectrometry is a rapid and easy-to-perform identification method. The effectiveness of a commercial MALDI-TOF MS platform to identify filamentous fungi in a clinical laboratory was evaluated. The study included 67 fungal isolates from 35 species/species complexes, which were identified and confirmed in mycology reference laboratories; 32 derived from clinical samples, 34 from strain collections and one was an ATCC strain. The study used the VITEK<jats:sup>®</jats:sup> MS system (v3.2.0 database), after sample extraction by VITEK<jats:sup>®</jats:sup> MS Mould Kit. Results were classified as “correct species”, “correct species complex”, “correct genus”and “no identification”. VITEK<jats:sup>®</jats:sup> MS correctly identified 91.0% of isolates (58.2% to species, 29.9% to species complex, and 1.5% to genus level only). In 82%, the result matched the species/species complex identified by reference methods. No misidentifications were observed. The kit was rapid and easy to use. In conclusion, the VITEK<jats:sup>®</jats:sup> MS system showed a high capability to accurately identify filamentous fungi in a clinical laboratory.</jats:p>
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    Item type:Publication,
      4Scopus© Citations 9
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    A Multicenter Study To Evaluate Ceftaroline Breakpoints: Performance in an Area with High Prevalence of Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Lineage
    (2019)
    Ayesha Khan
    ;
    Lina M. Rivas
    ;
    Maria Spencer
    ;
    Rodrigo Martinez
    ;
    Marusella Lam
    <jats:p> Ceftaroline (CPT) is a broad-spectrum agent with potent activity against methicillin-resistant <jats:named-content content-type="genus-species">Staphylococcus aureus</jats:named-content> (MRSA). The sequence type 5 (ST5) Chilean-Cordobés clone, associated with CPT nonsusceptibility, is dominant in Chile, a region with high rates of MRSA infections. </jats:p>
      1Scopus© Citations 7  1