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Self-reported Snoring Patterns Predict Stroke Events in High-Risk Patients With OSA
(2020)
Jingwei Li
;
R. Doug McEvoy
;
Danni Zheng
;
Kelly A. Loffler
;
Xia Wang
Scopus© Citations 25 2
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Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
(2016)
Danni Zheng
;
Hisatomi Arima
;
Shoichiro Sato
;
Antonio Gasparrini
;
Emma Heeley
1 1Scopus© Citations 24
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Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies
(2016)
Cheryl Carcel
;
Shoichiro Sato
;
Danni Zheng
;
Emma Heeley
;
Hisatomi Arima
8Scopus© Citations 41
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Intracerebral hemorrhage location and outcome among INTERACT2 participants
(2017)
Candice Delcourt
;
Shoichiro Sato
;
Shihong Zhang
;
Else Charlotte Sandset
;
Danni Zheng
<jats:sec><jats:title>Objective:</jats:title><jats:p>To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Associations between ICH sites and poor outcomes (death [6] or major disability [3–5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively).</jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p>Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule.</jats:p></jats:sec><jats:sec><jats:title>ClinicalTrials.gov registration:</jats:title><jats:p>NCT00716079.</jats:p></jats:sec>
1Scopus© Citations 133
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Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies
(2017)
Candice Delcourt
;
Danni Zheng
;
Xiaoying Chen
;
Maree Hackett
;
Hisatomi Arima
8Scopus© Citations 26
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Sleep duration and risk of cardiovascular events: The SAVE study
(2020)
Jingwei Li
;
Danni Zheng
;
Kelly A Loffler
;
Xia Wang
;
R Doug McEvoy
<jats:sec><jats:title>Background and aim</jats:title><jats:p> Controversy exists regarding cardiovascular risk in relation to sleep duration. We determined sleep duration and major recurrent cardiovascular event associations in patients with obstructive sleep apnoea and established cardiovascular disease. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Secondary analyses of the international, multicenter, Sleep Apnea Cardiovascular Endpoints trial. Sleep duration was estimated from overnight home oximetry (ApneaLink monitor) used for obstructive sleep apnoea diagnosis. Cox proportional hazards models were used to determine associations of categorized sleep duration (<6 h, 6–8 h (reference), and >8 h) and major cardiovascular outcomes: primary composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and any hospitalization for unstable angina, heart failure, or transient ischemic attack; secondary composite of cardiac and cerebral (stroke/transient ischemic attack) events. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Oximetry-derived sleep duration estimates were available in 2687 participants (mean 61.2 years, 80.9% males) who experienced a total of 436 cardiovascular events over a mean follow-up of 3.7 years. Compared to the reference category, sleep duration was not associated with risk of the primary composite cardiovascular outcome (adjusted hazard ratio (HR) 1.00, 95% confidence interval 0.76–1.33, and HR 1.22, 95% confidence interval 0.98–1.52, for sleep duration <6 and >8 h, respectively). However, long sleep was associated with increased cerebral events (HR 1.67, 95% confidence interval 1.17–2.39; P = 0.005) and stroke alone (HR 1.79, 95% confidence interval 1.22–2.63; P = 0.003). </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Long sleep duration is associated with an increased risk of stroke but not cardiac events in obstructive sleep apnoea patients with existing cardiovascular disease. </jats:p></jats:sec><jats:sec><jats:title>Clinical trial registration</jats:title><jats:p> The trial is registered at ClinicalTrials.gov (NCT00738179). </jats:p></jats:sec>
8Scopus© Citations 27

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