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Hosts and vectors of scrub typhus in Chile: epidemiological study and molecular analyses of Orientia infection in rodents and rodent-associated mites
(Springer Science and Business Media LLC, 2024-12-18)
Constanza Martínez-Valdebenito
;
Gerardo Acosta-Jamett
;
Rayitray Abello
;
Ju Jiang
;
Allen L. Richards
<jats:title>Abstract</jats:title><jats:p><jats:italic>Candidatus</jats:italic> Orientia chiloensis causes scrub typhus over a wide geographical range in southern Chile. The life cycle, including vectors and reservoirs of this novel rickettsial pathogen, is incompletely understood. We analyzed rodent tissue and rodent-associated mite samples collected during a field study in six localities on Chiloé Island, where human scrub typhus cases have occurred. Using molecular methods, we detected <jats:italic>Orientia</jats:italic> DNA in 24.8% of rodents, belonging to five of seven captured species. <jats:italic>Orientia</jats:italic>-infection rates showed geographical variations, but were not influenced by rodent species, sex, age, and mite infestation. Phylogenetic analysis showed that <jats:italic>Orientia</jats:italic> sequences from trombiculid mites (<jats:italic>Proschoengastia eloisae</jats:italic>) were identical to those from scrub typhus patients from the same region. The results suggest that these rodent-associated mites serve as vectors and play an important role in the ecology of scrub typhus in southern Chile. Further studies are required to determine whether <jats:italic>Orientia</jats:italic>-infected rodents can also serve as reservoir of <jats:italic>Orientia</jats:italic> in Chile.</jats:p> <jats:p><jats:bold>Graphical Abstract</jats:bold></jats:p>
1Scopus© Citations 8
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Scrub typhus in Tierra del Fuego: a tropical rickettsiosis in a subantarctic region
(2021)
WEITZEL, THOMAS
;
AYLWIN RAMIREZ, MABEL CRISTINA
;
Constanza Martínez-Valdebenito
;
Gerardo Acosta-Jamett
;
Katia Abarca
10Scopus© Citations 10
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Identification of trombiculid mites (Acari: Trombiculidae) on rodents from Chiloé Island and molecular evidence of infection with Orientia species
(2020)
Gerardo Acosta-Jamett
;
Constanza Martínez-Valdebenito
;
Esperanza Beltrami
;
María Carolina Silva-de La Fuente
;
Ju Jiang
23 1Scopus© Citations 42
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Molecular Description of a Novel <i>Orientia</i> Species Causing Scrub Typhus in Chile
(2020)
Katia Abarca
;
Constanza Martínez-Valdebenito
;
Jenniffer Angulo
;
Ju Jiang
;
Christina M. Farris
1Scopus© Citations 78 1
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Novel Vector of Scrub Typhus in Sub-Antarctic Chile: Evidence From Human Exposure
(2021)
WEITZEL, THOMAS
;
María Carolina Silva-de la Fuente
;
Constanza Martínez-Valdebenito
;
Alexandr A Stekolnikov
;
Caricia Pérez
<jats:title>Abstract</jats:title> <jats:p>The exposure of a research team to chigger mites in southern Chile allowed the first identification of a trombiculid species as vector and reservoir of scrub typhus outside the tsutsugamushi triangle, providing unique insights into the ecology and transmission of this recently discovered rickettsial infection in South America.</jats:p>
Scopus© Citations 22 5
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Human seroepidemiology of Rickettsia and Orientia species in Chile – A cross-sectional study in five regions
(2020)
WEITZEL, THOMAS
;
Gerardo Acosta-Jamett
;
Ju Jiang
;
Constanza Martínez-Valdebenito
;
Christina M. Farris
11 1Scopus© Citations 11
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Mother-to-Child Transmission of Andes Virus through Breast Milk, Chile1
(2020)
Marcela Ferrés
;
Constanza Martínez-Valdebenito
;
Jenniffer Angulo
;
Carolina Henríquez
;
Jorge Vera-Otárola
Scopus© Citations 17 4
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Scrub typhus risk in travelers to southern Chile
(2019)
Thomas Weitzel
;
Gerardo Acosta-Jamett
;
Constanza Martínez-Valdebenito
;
Allen L. Richards
;
Martin P. Grobusch
2Scopus© Citations 16
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A Single-Nucleotide Polymorphism of αVβ3 Integrin Is Associated with the Andes Virus Infection Susceptibility
(2019)
Constanza Martínez-Valdebenito
;
Jenniffer Angulo
;
Nicole Le Corre
;
Claudia Marco
;
VIAL COX, MARIA CECILIA
<jats:p>The Andes Orthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as “TT” (coding leucine) and “CC” (coding proline), respectively. TT was present at a rate of 89.2% (66/74) among the first cohort of ANDV cases and at 60% (63/105) among exposed close-household contacts, who remained uninfected (p < 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4% of the exposed close-household contacts who remained uninfected. Logistic regression modeling for risk of infection had an OR of 6.2–12.6 (p < 0.05) in the presence of TT and well-known ANDV risk activities. Moreover, an OR of 7.3 was obtained when the TT condition was analyzed for two groups exposed to the same environmental risk. Host genetic background was found to have an important role in ANDV infection susceptibility, in the studied population.</jats:p>
Scopus© Citations 12 4
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Scrub Typhus in Continental Chile, 2016–2018
(2019)
WEITZEL, THOMAS
;
Constanza Martínez-Valdebenito
;
Gerardo Acosta-Jamett
;
Ju Jiang
;
Allen L. Richards
14Scopus© Citations 57

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