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Author: search.filters.author.Andrea Benedetti

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    Accuracy of Cytologic vs Histologic Specimens for Assessment of Programmed Cell Death Ligand-1 Expression in Non-Small Cell Lung Cancer
    (2024)
    Pattraporn Tajarernmuang
    ;
    Felipe Aliaga
    ;
    Amr J. Alwakeel
    ;
    Gamuchirai Tavaziva
    ;
    Kimberly Turner
      2Scopus© Citations 13
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    Diagnosis of Obstructive Sleep Apnea in Parkinson's Disease Patients: Is Unattended Portable Monitoring a Suitable Tool?
    (2015)
    Priti Gros
    ;
    Victoria P. Mery
    ;
    Anne-Louise Lafontaine
    ;
    Ann Robinson
    ;
    Andrea Benedetti
    <jats:p><jats:italic>Purpose.</jats:italic>Obstructive sleep apnea (OSA) is frequent in Parkinson’s disease (PD) and may contribute to nonmotor symptoms. Polysomnography (PSG) is the gold standard for OSA diagnosis. Unattended portable monitoring (PM) may improve access to diagnosis but has not been studied in PD. We assessed feasibility and diagnostic accuracy in PD.<jats:italic>Methods.</jats:italic>Selected PD patients without known OSA underwent home PM and laboratory PSG. The quality of PM signals (<jats:italic>n</jats:italic>= 28) was compared with matched controls. PM accuracy was calculated compared with PSG for standard apnea hypopnea index (AHI) thresholds.<jats:italic>Results.</jats:italic>Technical failure rate was 27.0% and airflow signal quality was lower than in controls. Sensitivity of PM was 84.0%, 36.4%, and 50.0% for AHI cut-offs of 5/h, 15/h, and 30/h, respectively, using the same cut-offs on PM. Specificity was 66.7%, 83.3%, and 100%, respectively. PM underestimated the AHI with a mean bias of 12.4/h. Discrepancy between PM and PSG was greater in those with more motor dysfunction.<jats:italic>Conclusion.</jats:italic>PM was adequate to “rule in” moderate or severe OSA in PD patients, but the failure rate was relatively high and signal quality poorer than in controls. PM overall underestimated the severity of OSA in PD patients, especially those with greater motor dysfunction.</jats:p>
      13Scopus© Citations 16
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    Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea
    (2017)
    Victoria P. Mery
    ;
    Priti Gros
    ;
    Anne-Louise Lafontaine
    ;
    Ann Robinson
    ;
    Andrea Benedetti
    <jats:sec><jats:title>Objective:</jats:title><jats:p>To assess the association between obstructive sleep apnea (OSA) and nonmotor symptoms (NMS), including cognitive dysfunction, in patients with Parkinson disease (PD).</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Patients with idiopathic PD, recruited from a movement disorder clinic, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index (AHI) ≥15/h. PD severity was assessed using the Hoehn &amp; Yahr (H&amp;Y) scale and the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). NMS were assessed using the Montreal Cognitive Assessment (MoCA), Epworth Sleepiness Scale (ESS), Fatigue Severity Scale, Apathy Scale, Beck Depression Inventory, Hospital Depression and Anxiety Scale, and PD sleep Scale.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Sixty-seven patients (61.2% male), mean age 64.4 (SD 9.9) years and motor MDS-UPDRS 21.9 (12.6) using levodopa equivalent dose (LED) 752.4 (714.6) mg/d, were studied. OSA occurred in 47 patients (61.6%, mean AHI 27.1/h, SD 20.2/h), and NMS in 57 patients (85%). ESS and MoCA were associated with the AHI (ESS β = 0.0670, <jats:italic>p</jats:italic> = 0.031; MoCA β = −0.0520, <jats:italic>p</jats:italic> = 0.043, adjusted for age, sex, body mass index, LED, and H&amp;Y). ESS was associated with respiratory arousals (β = 0.1015, <jats:italic>p</jats:italic> = 0.011) and intermittent hypoxemia (β = 0.1470, <jats:italic>p</jats:italic> = 0.006). MoCA was negatively associated with respiratory arousals (β = −0.0596, <jats:italic>p</jats:italic> = 0.049) but not intermittent hypoxemia.</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>OSA is associated with sleepiness and cognitive dysfunction in PD, suggesting that OSA may be a reversible contributor to these NMS. Further studies will be required to evaluate whether OSA treatment can improve excessive sleepiness and cognitive dysfunction in PD.</jats:p></jats:sec>
    Scopus© Citations 53  2
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    Change in cognition and other non-motor symptoms with obstructive sleep apnea treatment in Parkinson disease
    (2018)
    Marta Kaminska
    ;
    Victoria P. Mery
    ;
    Anne-Louise Lafontaine
    ;
    Ann Robinson
    ;
    Andrea Benedetti
      14Scopus© Citations 62
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    Obstructive sleep apnea, CPAP therapy and Parkinson's disease motor function: A longitudinal study
    (2020)
    Lingrui Meng
    ;
    Andrea Benedetti
    ;
    Anne-Louise Lafontaine
    ;
    Victoria Mery
    ;
    Ann Ross Robinson
      1Scopus© Citations 41