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Item type:Publication, Early Postoperative Results in Robotic-Arm-Assisted Total Knee Replacement versus Conventional Technique: First Latin American Experience(2023); Scopus© Citations 1 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Intraarticular Administration of Dexamethasone after Mesenchymal Stem Cells Implantation Does Not Improve Significantly the Treatment of Preestablished Full-Thickness Chondral Defect in a Rabbit Model(2013); Marcela Gallegos<jats:sec><jats:title>Objective:</jats:title><jats:p> The aim of this study was to evaluate the contribution to hyaline cartilage regeneration of dexamethasone intraarticular administration after autologous mesenchymal stem cells (MSCs) implantation into a preestablished knee full-thickness chondral defect. </jats:p></jats:sec><jats:sec><jats:title>Design:</jats:title><jats:p> Full-thickness chondral defects of 4.5 × 4.5 mm<jats:sup>2</jats:sup> were surgically made in both medial femoral condyles of adult male New Zealand rabbits. Two weeks later, autologous ex vivo expanded bone marrow–derived MSCs were embedded in hyaluronic acid and implanted into the chondral defects. Immediately and every week after the intervention, dexamethasone 0.25 mg/kg was intraarticularly administered (MSC/dexa-treated group). Six weeks after MSC transplantation, the animals were euthanized and condyles were characterized molecularly according to aggrecan, collagen type II, and collagen type I gene expression (quantitative reverse transcriptase-polymerase chain reaction) and histologically (hematoxylin–eosin staining). Data of MSC/dexa-treated condyles were compared with untreated, dexa-treated, MSC-treated, or normal unlesioned condyles. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> The ratio between collagen type II expression versus collagen type I expression in MSC/dexa-treated condyles was higher than one, even though the group mean value was not statistically different from that of untreated defects. Histological changes were observed between MSC/dexa-treated and untreated defects mainly in surface regularity and in hyaline matrix abundance. However, International Cartilage Repair Society score analysis did not support robust differences between those groups. </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> Intraarticular administration of dexamethasone after autologous MSC implantation into a preestablished full-thickness chondral defect does not contribute significantly to the regeneration of a tissue with molecular and histological characteristics identical to hyaline cartilage. </jats:p></jats:sec>1Scopus© Citations 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of tendon tensioning: An in vitro study in porcine extensor tendons(2010); ; 5 1Scopus© Citations 18 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Fracture Dislocation of the Glenoid Fossa With Open Physis: A Case Report(2010)2Scopus© Citations 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Magnetic Resonance Imaging Evaluation of the Integration and Maturation of Semitendinosus-Gracilis Graft in Anterior Cruciate Ligament Reconstruction Using Autologous Platelet Concentrate(2010); ; 1Scopus© Citations 107 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Scopus© Citations 20 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Osteochondral autografts in full thickness patella cartilage lesions(2011); ; 1 1Scopus© Citations 26 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinical outcomes after arthroscopic treatment of knee osteoarthritis(2013); ; 26 1Scopus© Citations 19 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Knee Chondral Lesions: Incidence and Correlation Between Arthroscopic and Magnetic Resonance Findings(2007); ; Scopus© Citations 128 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Vancomycin presoaking of hamstring autografts to prevent infection in anterior cruciate ligament reconstruction: a narrative review(2021); ; ; João Espregueira-Mendes<jats:p> Hamstring autograft use has been linked to an increased risk of infection after anterior cruciate (ACL) reconstruction compared to other grafts. The absolute reason for this remains unclear, with contamination after harvesting and preparation of the graft being the most accepted hypothesis. Using the rationale that a contaminated graft could be the main factor in postoperative septic arthritis and in an effort to maximize the antibiotic efficacy of the graft, the Vancomycin presoaking technique was developed. It has shown success in decreasing the infection rate in ACL reconstruction. In recent years, an important number of research articles using this protocol have appeared, but the technique is still not widely implemented. Recent literature shows that Vancomycin presoaking of the graft has shown a successful decrease in the infection rate after hamstring autograft ACL reconstruction. It has also shown efficacy decreasing the infection rate in other types of grafts (patellar tendon, quadriceps tendon, allograft) and also in patients with concomitant ligament procedures or open surgeries. Despite the positive effects of Vancomycin presoaking reducing the infection rate after ACL reconstruction, the lack of prospective randomized control trials and the heterogeneity of the different studies mean it is not feasible to recommend Vancomycin presoaking of the graft universally for every ACL reconstruction patient. </jats:p><jats:p> Cite this article: EFORT Open Rev 2021;6:211-216. DOI: 10.1302/2058-5241.6.200059 </jats:p>1Scopus© Citations 7
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