Universidad del Desarrollo

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Proteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality
(2021)
LOPEZ HERNANDEZ, RENE RAMON
;
Gregory Mertz
;
GRAF SANTOS, JERÓNIMO
;
Mauricio Espinoza
;
Marcela Ferrés
27Scopus© Citations 4
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Enfermedad relacionada a IgG4. Serie clínica de pacientes chilenos
(2022)
María C. Cuéllar
;
Miguel Gutiérrez
;
Alejandra Herrera
;
Fabián Elgueta
;
Pamela Wurmann
Scopus© Citations 1 4
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Identification of trombiculid mites (Acari: Trombiculidae) on rodents from Chiloé Island and molecular evidence of infection with Orientia species
(2020)
Gerardo Acosta-Jamett
;
Constanza Martínez-Valdebenito
;
Esperanza Beltrami
;
María Carolina Silva-de La Fuente
;
Ju Jiang
23 1Scopus© Citations 42
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The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology Points to Consider for Diagnosis and Management of Autoinflammatory Type I Interferonopathies:
<scp>CANDLE</scp>
/
<scp>PRAAS</scp>
,
<scp>SAVI</scp>
, and
<scp>AGS</scp>
(2022)
Kader Cetin Gedik
;
Lovro Lamot
;
Micol Romano
;
Erkan Demirkaya
;
David Piskin
Scopus© Citations 36 1
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Factors associated with neuropsychiatric involvement in Latin American patients with systemic lupus erythematosus
(2021)
Leonor A Barile-Fabris
;
Hilda Fragoso-Loyo
;
Daniel Wojdyla
;
Rosana Quintana
;
Guillermo J Pons-Estel
<jats:sec><jats:title>Introduction</jats:title><jats:p> Factors related to presentation of neuropsychiatric (NP) SLE manifestations, early in the course of the disease, and during follow up have not been clearly established. </jats:p></jats:sec><jats:sec><jats:title>Purpose</jats:title><jats:p> To identify disease and non-disease related factors associated with NP manifestations in early SLE. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> We included 1193 patients from the GLADEL inception cohort free of NP involvement at cohort entry. We evaluated the association of demographic, clinical and laboratory data with NP involvement during follow-up. </jats:p></jats:sec><jats:sec><jats:title>Statistical methods</jats:title><jats:p> Independent factors associated with NP involvement were identified using a multivariable Cox regression model. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Factors independently associated with NP manifestations were: mestizo ethnicity (HR 1.701, 95% CI 1.282–2.258, p = 0.0002), myalgias/myositis (HR 1.832, 95% CI 1.335–2.515, p = 0.0002), pneumonitis (HR 2.476, 95% CI 1.085–5.648, p = 0.0312), shrinking lung (HR 2.428, 95% CI 1.074–5.493, p = 0.0331) and hemolytic anemia (HR 1.629, 95% CI 1.130–2.347, p = 0.0089). Longer disease duration at cohort entry (13 to 24 months) was associated with a lower risk of developing NP manifestations (HR 0.642, 95% CI 0.441–0.934, p = 0.0206). </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Patients with myalgias/myositis, pneumonitis, shrinking lung and hemolytic anemia are at higher risk of NP involvement, whereas longer disease duration at cohort entry is associated with a lower risk of developing NP involvement. </jats:p></jats:sec>
15Scopus© Citations 3
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Targeted high volume hemofiltration could avoid extracorporeal membrane oxygenation in some patients with severe Hantavirus cardiopulmonary syndrome
(2021)
LOPEZ HERNANDEZ, RENE RAMON
;
Rodrigo Pérez‐Araos
;
Álvaro Salazar
;
Mauricio Espinoza
;
Analia Cuiza
Scopus© Citations 10 1
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Caffeine Prevents Hyperoxia-Induced Functional and Structural Lung Damage in Preterm Rabbits
(2016)
Taro Nagatomo
;
Julio Jiménez
;
Jute Richter
;
Siegrid De Baere
;
Jeroen Vanoirbeek
<jats:p>Background: Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth. Objectives: To study the inflammatory, structural and functional effects of caffeine in an animal model of BPD. Methods: Preterm New Zealand-Dendermonde rabbits (gestational day 28; term 31) were randomized to three groups: normoxia-placebo (N-P), hyperoxia-placebo (H-P) and hyperoxia-caffeine (H-C). Lung function was assessed on postnatal day 5, along with airway morphometry, vascular morphometry and a score observing airway inflammation. Results: Caffeine improved lung function by increasing lung volume [mean displaced volume N-P: 40.1 ± 6 ml/kg, H-P: 27.8 ± 8 ml/kg and H-C: 34.4 ± 7 ml/kg (p < 0.05); total lung capacity: N-P: 1.17 ± 0.1 ml, H-P: 0.67 ± 0.1 ml and H-C: 1.1 ± 0.1 ml (p < 0.05)], decreasing tissue damping [N-P: 2.7 ± 0.3 cm H2O/ml, H-P: 4.6 ± 0.6 cm H2O/ml and H-C: 3.2 ± 0.4 cm H2O/ml (p < 0.05)], elastance [N-P: 9.3 ± 2.4 cm H2O/ml, H-P: 19.2 ± 7.4 cm H2O/ml and H-C: 10.7 ± 2 cm H2O/ml (p < 0.05)] and compliance [N-P: 0.06 ± 0.01 cm H2O/ml, H-P: 0.054 ± 0.01 cm H2O/ml and H-C: 0.07 ± 0.013 cm H2O/ml (p < 0.05)]. Caffeine also improved histology by decreasing alveolar size [linear intercepts; N-P: 83.6 ± 1.7, H-P: 82.9 ± 1.6 and H-C: 67.3 ± 1.4 (p < 0.05)], increasing radial alveolar count (N-P: 6.6 ± 0.5, H-P: 5.7 ± 0.6 and H-C: 7.05 ± 0.5) and decreasing the acute inflammation score [N-P: 0.3 ± 0.1, H-P: 0.5 ± 0.1 and H-C: 0.4 ± 0.1 (p < 0.05)]. Conclusion: In preterm rabbits, caffeine reduces the functional, architectural and inflammatory pulmonary changes induced by hyperoxia in the lung.</jats:p>
6Scopus© Citations 50
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Dendriform Pulmonary Ossification
(2015)
Sebastián, Fernandez-Bussy
;
G. Labarca
;
Y. Pires
;
J. C. Diaz
;
CAVIEDES SOTO, IVAN RICARDO
5Scopus© Citations 27
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Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study
(2019)
Georgina V Long
;
Reinhard Dummer
;
Omid Hamid
;
Thomas F Gajewski
;
Christian Caglevic
Scopus© Citations 731 3

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