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    Enfermedad relacionada a IgG4. Serie clínica de pacientes chilenos
    (2022)
    María C. Cuéllar
    ;
    Miguel Gutiérrez
    ;
    Alejandra Herrera
    ;
    Fabián Elgueta
    ;
    Pamela Wurmann
    Scopus© Citations 1  4
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    El riñón del niño prematuro: riesgos a largo plazo
    (2020)
    Felipe Cavagnaro SM.
    <jats:p>El recién nacido prematuro se enfrenta a las condiciones extrauterinas con sistemas aún inmaduros, tanto anatómica como fisiológicamente. El riñón termina de desarrollarse a finales del tercer trimestre del embarazo, por lo que está especialmente expuesto a alterar su desarrollo normal en caso de nacer en forma prematura. Esta situación puede condicionar, entre otras consecuencias, una menor masa renal funcional y cambios microvasculares que representan un riesgo elevado de hipertensión arterial y daño renal crónico en el largo plazo. En el presente artículo se analiza la evidencia existente actual sobre estos riesgos en los prematuros y se ofrece un esquema de seguimiento de estos niños desde el punto de vista nefrológico.</jats:p>
      9Scopus© Citations 5
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      9  1
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    Virtual Unenhanced Images at Dual-Energy CT: Influence on Renal Lesion Characterization
    (2019)
    Mathias Meyer
    ;
    Rendon C. Nelson
    ;
    Federica Vernuccio
    ;
    GONZALEZ COFRE, FERNANDO OMAR  
    ;
    Alfredo E. Farjat
      1Scopus© Citations 66
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    Correlation of preoperative imaging characteristics with donor outcomes and operative difficulty in laparoscopic donor nephrectomy
    (2020)
    Fides R. Schwartz
    ;
    Brian I. Shaw
    ;
    Reginald Lerebours
    ;
    Federica Vernuccio
    ;
    Francesca Rigiroli
    Scopus© Citations 6  19
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    Identification and characterization of miRNAs and lncRNAs of coho salmon (Oncorhynchus kisutch) in normal immune organs.
    (2020)
    Francisco Leiva
    ;
    Marcelo Herrera
    ;
    Daniela Reyes
    ;
    Scarleth Bravo
    ;
    Killen Ko Garcia
    Scopus© Citations 19  3
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    Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors
    (2020)
    Pablo Lara
    ;
    Sujey Palma-Florez
    ;
    Edison Salas-Huenuleo
    ;
    Iva Polakovicova
    ;
    Simón Guerrero
    <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they have a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at defined sites, including tumors. Analyzing the potential of EVs to target specific cells remains challenging, considering the unspecific binding of lipophilic tracers to other proteins, the limitations of fluorescence for deep tissue imaging and the effect of external labeling strategies on their natural tropism. In this work, we determined the cell-type specific tropism of B16F10-EVs towards cancer cell and metastatic tumors by using fluorescence analysis and quantitative gold labeling measurements. Surface functionalization of plasmonic gold nanoparticles was used to promote indirect labeling of EVs without affecting size distribution, polydispersity, surface charge, protein markers, cell uptake or in vivo biodistribution. Double-labeled EVs with gold and fluorescent dyes were injected into animals developing metastatic lung nodules and analyzed by fluorescence/computer tomography imaging, quantitative neutron activation analysis and gold-enhanced optical microscopy.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We determined that B16F10 cells preferentially take up their own EVs, when compared with colon adenocarcinoma, macrophage and kidney cell-derived EVs. In addition, we were able to detect the preferential accumulation of B16F10 EVs in small metastatic tumors located in lungs when compared with the rest of the organs, as well as their precise distribution between tumor vessels, alveolus and tumor nodules by histological analysis. Finally, we observed that tumor EVs can be used as effective vectors to increase gold nanoparticle delivery towards metastatic nodules.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Our findings provide a valuable tool to study the distribution and interaction of EVs in mice and a novel strategy to improve the targeting of gold nanoparticles to cancer cells and metastatic nodules by using the natural properties of malignant EVs.</jats:p> </jats:sec>
      11  1Scopus© Citations 88