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    Scopus© Citations 35  3
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    An integrated multi-criteria decision analysis and optimization modeling approach to spatially operational road repair decisions
    (2021)
    Sättar Ezzati
    ;
    PALMA INFANTE, CRISTIAN DERECK  
    ;
    Pete Bettinger
    ;
    Ljusk Ola Eriksson
    ;
    Anjali Awasthi
    In this study, we developed a generic cost-effective approach for spatially explicit decision support involving the allocation of road repair treatments. The approach begins with an assessment of the existing road condition to identify the extent of environmental impacts and to determine road repair regimes in a subjective manner using group-decision making efforts. An integer programming model is then formulated by combining expert opinions with operational costs to guide repair schedules required for each road segment at the operational planning level. To demonstrate model performance, we applied it to a 400 km<jats:sup>2</jats:sup> landscape consisting of 289 km of paved roads in the mountainous region of the Hyrcanian forests in Iran. We assessed sensitivity of the inputs, such as weight verification, budgetary limitations, and rehabilitation weights. The results of the subjective analysis show that 76% of the roads analyzed in these forests must be prioritized to receive treatments as intended for logistical purposes. Incorporating the extent of environmental dimensions into operational costs allows us to generate an optimal tradeoff curve by selecting an appropriate treatment for segments of a road network. The approach demonstrated here can be used to design detailed alternative solutions for addressing spatially-informed road decisions under various terrain conditions.
      4Scopus© Citations 5
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      3Scopus© Citations 17
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    Multi-feature computational framework for combined signatures of dementia in underrepresented settings
    (2022)
    Sebastian Moguilner
    ;
    Agustina Birba
    ;
    Sol Fittipaldi
    ;
    Cecilia Gonzalez-Campo
    ;
    Enzo Tagliazucchi
    <jats:title>Abstract</jats:title> <jats:p> <jats:italic>Objective.</jats:italic> The differential diagnosis of behavioral variant frontotemporal dementia (bvFTD) and Alzheimer’s disease (AD) remains challenging in underrepresented, underdiagnosed groups, including Latinos, as advanced biomarkers are rarely available. Recent guidelines for the study of dementia highlight the critical role of biomarkers. Thus, novel cost-effective complementary approaches are required in clinical settings. <jats:italic>Approach</jats:italic>. We developed a novel framework based on a gradient boosting machine learning classifier, tuned by Bayesian optimization, on a multi-feature multimodal approach (combining demographic, neuropsychological, magnetic resonance imaging (MRI), and electroencephalography/functional MRI connectivity data) to characterize neurodegeneration using site harmonization and sequential feature selection. We assessed 54 bvFTD and 76 AD patients and 152 healthy controls (HCs) from a Latin American consortium (ReDLat). <jats:italic>Main results</jats:italic>. The multimodal model yielded high area under the curve classification values (bvFTD patients vs HCs: 0.93 (±0.01); AD patients vs HCs: 0.95 (±0.01); bvFTD vs AD patients: 0.92 (±0.01)). The feature selection approach successfully filtered non-informative multimodal markers (from thousands to dozens). <jats:italic>Results</jats:italic>. Proved robust against multimodal heterogeneity, sociodemographic variability, and missing data. <jats:italic>Significance</jats:italic>. The model accurately identified dementia subtypes using measures readily available in underrepresented settings, with a similar performance than advanced biomarkers. This approach, if confirmed and replicated, may potentially complement clinical assessments in developing countries.</jats:p>
    Scopus© Citations 19  1  3