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Item type:Publication, Carbapenem-resistant Enterobacterales in solid organ transplant recipients(2024)1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in
<i>Pseudomonas aeruginosa</i>
of clinical origin(2024); JOSE RODRIGO WALDEMAR MARTINEZ SOLIS<jats:title>ABSTRACT</jats:title> <jats:sec> <jats:title/> <jats:p> The siderophore-cephalosporin cefiderocol (FDC) presents a promising treatment option for carbapenem-resistant (CR) <jats:italic>P. aeruginosa</jats:italic> (PA). FDC circumvents traditional porin and efflux-mediated resistance by utilizing TonB-dependent receptors (TBDRs) to access the periplasmic space. Emerging FDC resistance has been associated with loss of function mutations within TBDR genes or the regulatory genes controlling TBDR expression. Further, difficulties with antimicrobial susceptibility testing (AST) and unexpected negative clinical treatment outcomes have prompted concerns for heteroresistance, where a single lineage isolate contains resistant subpopulations not detectable by standard AST. This study aimed to evaluate the prevalence of TBDR mutations among clinical isolates of <jats:italic>P. aeruginosa</jats:italic> and the phenotypic effect on FDC susceptibility and heteroresistance. We evaluated the sequence of <jats:italic>pirR</jats:italic> , <jats:italic>pirS</jats:italic> , <jats:italic>pirA</jats:italic> , <jats:italic>piuA</jats:italic> , or <jats:italic>piuD</jats:italic> from 498 unique isolates collected before the introduction of FDC from four clinical sites in Portland, OR (1), Houston, TX (2), and Santiago, Chile (1). At some clinical sites, TBDR mutations were seen in up to 25% of isolates, and insertion, deletion, or frameshift mutations were predicted to impair protein function were seen in 3% of all isolates ( <jats:italic>n</jats:italic> = 15). Using population analysis profile testing, we found that <jats:italic>P. aeruginosa</jats:italic> with major TBDR mutations were enriched for a heteroresistant phenotype and undergo a shift in the susceptibility distribution of the population as compared to susceptible strains with wild-type TBDR genes. Our results indicate that mutations in TBDR genes predate the clinical introduction of FDC, and these mutations may predispose to the emergence of FDC resistance. </jats:p> </jats:sec>Scopus© Citations 18 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Multisite Detection of Tn
<i>1549</i>
-Mediated
<i>vanB</i>
Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida(2023)7 1Scopus© Citations 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Corrigendum to “<i>In Vivo</i> Resistance to Ceftolozane/Tazobactam in <i>Pseudomonas aeruginosa</i> Arising by AmpC- and Non-AmpC-Mediated Pathways”(2019)4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, <i>In Vivo</i> Resistance to Ceftolozane/Tazobactam in <i>Pseudomonas aeruginosa</i> Arising by AmpC- and Non-AmpC-Mediated Pathways(2018)4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Influence of Inoculum Effect on the Efficacy of Daptomycin Monotherapy and in Combination with beta-Lactams against Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions(2018)3 1Scopus© Citations 37