Browsing by Type "journal-article"
Now showing 1 - 20 of 951
Results Per Page
Sort Options
- Some of the metrics are blocked by yourconsent settings
Publication 1725P Metastasis-resident bacteria in advanced hormone receptor-positive breast cancer are related to primary tumor microbiota and show distinct composition(2022) ;C. Araya ;S. Contreras-Riquelme ;B. Mino ;F.J. Perez ;A.J. Martin13 - Some of the metrics are blocked by yourconsent settings
Publication 4 Domain Sports PROM en español: adaptación transcultural en la población chilena y análisis de confiabilidad(2024); ;RENÉ GUILOFF; ;Esteban StockerS. Rocha Piedade22 - Some of the metrics are blocked by yourconsent settings
Publication A 100-day mentoring program leads to positive shifts in girls’ perceptions and attitudes towards biomechanics and related STEM disciplines(2024) ;Taylor J.M. Dick; ;Celeste E. Coltman ;Laura E. Diamond ;Michelle Hall ;Jayishni Maharaj ;Crystal O. Kean ;Martina BarzanKaren J. Mickle12 - Some of the metrics are blocked by yourconsent settings
Publication A case of diffuse kidney hyperechogenicity in early childhood associated with biallelic PKHD1 variants(2024) ;Paola Krall ;Víctor Faundes ;Carla GálvezCARLOS FELIPE GONZALO CAVAGNARO SANTA MARIA8 - Some of the metrics are blocked by yourconsent settings
Publication A case report of sarcoidosis and ulcerative colitis: overlap or coexistence(Sociedad Espanola de Patologia Digestiva (SEPD), 2024) ;Alex Fabián Arenas Aravena ;Diego Ruedi ;Matías Sanhueza; ;Gonzalo Carrasco-AvinoPatricio Ibáñez - Some of the metrics are blocked by yourconsent settings
Publication A Comparative Analysis of Universal and Sentinel Surveillance Data for Coronavirus Disease 2019: Insights From Argentina, Chile, and Mexico (2020–2022)(Oxford University Press (OUP), 2025-03-10) ;Lidia Redondo-Bravo ;Kinda Zureick ;Carla Voto ;Xaviera Molina Avendaño ;Laura Flores-Cisneros ;Ashley Fowlkes ;Luciana Eva Iummato ;Carlos Giovacchini ;Maria Fernanda Olivares Barraza ;Paula Rodriguez Ferrari ;Rosaura Gutiérrez-Vargas ;Christian Arturo Zaragoza-Jiménez ;Gabriel García-Rodríguez ;Hugo López-Gatell ;Ángel Rodríguez ;Paula Couto ;Marc RondyAndrea S Vicari - Some of the metrics are blocked by yourconsent settings
Publication A Comprehensive Analysis of the Effect of A>I(G) RNA-Editing Sites on Genotoxic Drug Response and Progression in Breast Cancer(2024) ;Yanara A. Bernal ;Alejandro Blanco ;Eduardo A. Sagredo ;Karen Oróstica ;Ivan Alfaro ;Katherine MarcelainDysregulated A>I(G) RNA editing, which is mainly catalyzed by ADAR1 and is a type of post-transcriptional modification, has been linked to cancer. A low response to therapy in breast cancer (BC) is a significant contributor to mortality. However, it remains unclear if there is an association between A>I(G) RNA-edited sites and sensitivity to genotoxic drugs. To address this issue, we employed a stringent bioinformatics approach to identify differentially RNA-edited sites (DESs) associated with low or high sensitivity (FDR 0.1, log2 fold change 2.5) according to the IC50 of PARP inhibitors, anthracyclines, and alkylating agents using WGS/RNA-seq data in BC cell lines. We then validated these findings in patients with basal subtype BC. These DESs are mainly located in non-coding regions, but a lesser proportion in coding regions showed predicted deleterious consequences. Notably, some of these DESs are previously reported as oncogenic variants, and in genes related to DNA damage repair, drug metabolism, gene regulation, the cell cycle, and immune response. In patients with BC, we uncovered DESs predominantly in immune response genes, and a subset with a significant association (log-rank test p < 0.05) between RNA editing level in LSR, SMPDL3B, HTRA4, and LL22NC03-80A10.6 genes, and progression-free survival. Our findings provide a landscape of RNA-edited sites that may be involved in drug response mechanisms, highlighting the value of A>I(G) RNA editing in clinical outcomes for BC.3 - Some of the metrics are blocked by yourconsent settings
Publication A consistent moment equations for binary probit models with endogenous variables using instrumental variables(2024) ;Louis de Grange; ;Matthieu Marechal - Some of the metrics are blocked by yourconsent settings
Publication A framework for investigating new firm entry: The (limited) overlap between informal-formal and necessity-opportunity entrepreneurship(2024) ;Saul Estrin; Tomasz Mickiewicz2 - Some of the metrics are blocked by yourconsent settings
Publication A home hospitalization assignment and routing problem with multiple time windows, mandatory returns and perishable biological samples: A Chilean case study(2024); ;Franco Basso; ;Juan Pablo Contreras ;Raúl Pezoa ;María Francisca Rojas-GoldsackRONCO, RICARDO3 - Some of the metrics are blocked by yourconsent settings
Publication A horizontal collaboration approach for grape transportation in a pisco cooperative(Elsevier BV, 2025-02) ;Franco Basso ;Carlos A. Monardes-Concha ;Francisco Lorca ;Raúl Pezoa - Some of the metrics are blocked by yourconsent settings
Publication A mathematical model of semantic access in lexical and semantic decisions(2024) ;Sergio E. Chaigneau ;Nicolás Marchant ;Enrique CanessaNerea AldunateIn this work, we use a mathematical model of the property listing task dynamics and test its ability to predict processing time in semantic and lexical decision tasks. The study aims at exploring the temporal dynamics of semantic access in these tasks and showing that the mathematical model captures essential aspects of semantic access, beyond the original task for which it was developed. In two studies using the semantic and lexical decision tasks, we used the mathematical model’s coefficients to predict reaction times. Results showed that the model was able to predict processing time in both tasks, accounting for an independent portion of the total variance, relative to variance predicted by traditional psycholinguistic variables (i.e., frequency, familiarity, concreteness imageability). Overall, this study provides evidence of the mathematical model’s validity and generality, and offers insights regarding the characterization of concrete and abstract words.9 - Some of the metrics are blocked by yourconsent settings
Publication A Multidimensional, Person-Centered Framework for Functional Assessment in Dementia: Insights from the ‘What’, ‘How’, ‘To Whom’, and ‘How Much’ Questions(2024); ;Fabrissio Grandi ;Daniela Thumala ;Sandra Baez ;Hernando Santamaria-García ;Maureen Schmitter-EdgecombeMario A. ParraDementia is a syndrome characterized by cognitive and neuropsychiatric symptoms associated with progressive functional decline (FD). FD is a core diagnostic criterion for dementia, setting the threshold between its prodromal stages and the full-blown disease. The operationalization of FD continues to generate a great deal of controversy. For instance, the threshold of FD for the diagnosis of dementia varies across diagnostic criteria, supporting the need for standardization of this construct. Moreover, there is a need to reconsider how we are measuring FD to set boundaries between normal aging, mild cognitive impairment, and dementia. In this paper, we propose a multidimensional framework that addresses outstanding issues in the assessment of FD: i) What activities of daily living (ADLs) are necessary to sustain an independent living in aging? ii) How to assess FD in individuals with suspected neurocognitive disorders? iii) To whom is the assessment directed? and iv) How much does FD differentiate healthy aging from mild and major neurocognitive disorders? Importantly, the To Whom Question introduces a person-centered approach that regards patients and caregivers as active agents in the assessment process of FD. Thus, once impaired ADLs have been identified, patients can indicate how significant such impairments are for them in daily life. We envisage that this new framework will guide future strategies to enhance functional assessment and treatment of patients with dementia and their caregivers.25 - Some of the metrics are blocked by yourconsent settings
Publication A multimodal interface for speech perception: the role of the left superior temporal sulcus in social cognition and autism(2024) ;Leonie Kausel ;Maëva Michon; Francisco AboitizAbstract Multimodal integration is crucial for human interaction, in particular for social communication, which relies on integrating information from various sensory modalities. Recently a third visual pathway specialized in social perception was proposed, which includes the right superior temporal sulcus (STS) playing a key role in processing socially relevant cues and high-level social perception. Importantly, it has also recently been proposed that the left STS contributes to audiovisual integration of speech processing. In this article, we propose that brain areas along the right STS that support multimodal integration for social perception and cognition can be considered homologs to those in the left, language-dominant hemisphere, sustaining multimodal integration of speech and semantic concepts fundamental for social communication. Emphasizing the significance of the left STS in multimodal integration and associated processes such as multimodal attention to socially relevant stimuli, we underscore its potential relevance in comprehending neurodevelopmental conditions characterized by challenges in social communication such as autism spectrum disorder (ASD). Further research into this left lateral processing stream holds the promise of enhancing our understanding of social communication in both typical development and ASD, which may lead to more effective interventions that could improve the quality of life for individuals with atypical neurodevelopment.13 - Some of the metrics are blocked by yourconsent settings
Publication A Narrative Review about Metabolic Pathways, Molecular Mechanisms and Clinical Implications of Intermittent Fasting as Autophagy Promotor(Springer Science and Business Media LLC, 2025-06-06) ;Álvaro Andrés Vergara Nieto ;Andrés Halabi Diaz ;Millaray HernándezDaniel Sagredo - Some of the metrics are blocked by yourconsent settings
Publication A Natural deep eutectic solvent as an effective material for dual debridement and antibiofilm effects in chronic wound treatment(2024); ; ; ; ;Constanza Cárcamo ;Fabián Martinez-Gómez ;Isabel Aburto; ;Bernardo Morales10 - Some of the metrics are blocked by yourconsent settings
Publication A Novel Homozygous 9385 bp Deletion in the FERMT1 (KIND1) Gene in a Malaysian Family with Kindler Epidermolysis bullosa and a Review of Large Deletions(MDPI AG, 2025-04-29) ;Alfred Klausegger ;Fabian Leditzky ;Susanne Krämer; ; ;Sebastián Véliz ;Mark Jean Aan Koh ;Ene-Choo Tan ;Martin Laimer ;Johann Wolfgang BauerKindler Epidermolysis bullosa (KEB; OMIM 173650) is a rare autosomal recessive genodermatosis characterized by bullous poikiloderma and photosensitivity. Additional presentations include blistering, poor wound healing, skin atrophy, and increased risk of skin cancer. Most cases of KEB result from aberrations in the FERMT1 (Fermitin family member 1) gene encoding kindlin-1 and include nonsense, frameshift, splicing, and missense variants. Large deletion variants have been reported in nine cases to date. Most variants are predicted to lead to premature termination of translation and to loss of kindlin-1 function. In this study, we report on a 33-year-old male patient who presented with typical clinical manifestations of KEB. As routine molecular testing failed to obtain a diagnosis, Next Generation Sequencing (NGS) of an Epidermolysis Bullosa (EB)-specific panel was carried out followed by the determination of the deletion breakpoints and verification at the mRNA and protein levels. This approach revealed a new large homozygous deletion of ~9.4 kb in the FERMT1 gene involving exons 7 to 9. Finally, we performed a literature review on large FERMT1 deletions. The deletion is predicted to skip exons 7 to 9 within the mRNA, which results in a frameshift. The patient’s phenotype is likely caused by the resulting truncated and non-functioning protein. Our report further enriches the spectrum of FERMT1 gene variants to improve genotype–phenotype correlations. - Some of the metrics are blocked by yourconsent settings
Publication A Simple Machine Learning-Based Quantitative Structure–Activity Relationship Model for Predicting pIC50 Inhibition Values of FLT3 Tyrosine Kinase(MDPI AG, 2025-01-14); ;Ignacio Sánchez ;Cristian Merino ;Bruno Monasterio ;Gaspar Sajuria ;Diego Miranda ;Felipe DíazBackground/Objectives: Acute myeloid leukemia (AML) presents significant therapeutic challenges, particularly in cases driven by mutations in the FLT3 tyrosine kinase. This study aimed to develop a robust and user-friendly machine learning-based quantitative structure–activity relationship (QSAR) model to predict the inhibitory potency (pIC50 values) of FLT3 inhibitors, addressing the limitations of previous models in dataset size, diversity, and predictive accuracy. Methods: Using a dataset which was 14 times larger than those employed in prior studies (1350 compounds with 1269 molecular descriptors), we trained a random forest regressor, chosen due to its superior predictive performance and resistance to overfitting. Rigorous internal validation via leave-one-out and 10-fold cross-validation yielded Q2 values of 0.926 and 0.922, respectively, while external validation on 270 independent compounds resulted in an R2 value of 0.941 with a standard deviation of 0.237. Results: Key molecular descriptors influencing the inhibitor potency were identified, thereby improving the interpretability of structural requirements. Additionally, a user-friendly computational tool was developed to enable rapid prediction of pIC50 values and facilitate ligand-based virtual screening, leading to the identification of promising FLT3 inhibitors. Conclusions: These results represent a significant advancement in the field of FLT3 inhibitor discovery, offering a reliable, practical, and efficient approach for early-stage drug development, potentially accelerating the creation of targeted therapies for AML. - Some of the metrics are blocked by yourconsent settings
Publication A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development(Springer Science and Business Media LLC, 2024-12-18) ;Cristóbal Vacarezza ;Julieta Araneda ;Pamela Gonzalez ;Oscar Arteaga ;Katherine Marcelain ;Enrique A. Castellon ;Ana Periera ;Maroun Khoury ;Bettina Müller; ; ;Arnoldo Riquelme ;Alejandro H. Corvalan ;Jorge Jiménez de la Jara ;Catterina Ferreccio ;Carolina Goic ;Bruno Nervi ;Juan Carlos RoaGareth I. OwenAbstract Introduction Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare and research systems are unprepared for the social and economic burden of cancer. One decade ago, the authors put forward a comprehensive analysis of cancer infrastructure, together with a series of suggestions on research orientated political policy. Objectives Provide an update and comment on policy, infrastructure, gender equality, stakeholder participation and new challenges in national oncology. Assess the funding and distribution of cancer investigation. Present actions for the development of oncology research, innovation and patient care. Methods Triangulating objective system metrics of economic, epidemiological, private and public sector resources together with policy analysis, we assessed cancer burden, infrastructure, and investigation. We analyzed governmental and private-sector cancer databases, complemented by interviews with cancer stakeholders. Results Governmental policy and patient advocacy have led to the recognition of cancer burden, a cancer law, and a national cancer plan. Cancer has become the leading cause of death in Chile (59,876 cases and 31,440 cancer deaths in 2022), yet only 0.36% gross domestic product (GDP) is directed to research and development. Inequalities in treatment regimens persist. Prevention policy has lowered tobacco consumption, sugar intake via soft drinks and offered a high coverage of HPV vaccines. A high-quality cancer research community is expanding, and internationally sponsored clinical oncology trials are increasing. Conclusions The cancer law has facilitated advancement in policy. Prevention policies have impacted tobacco and sugar intake, while gender equality and care inequality have entered the public forum. Cancer research is stagnated by the lack of investment. Implementation of a cancer registry and biobanking, reinforcement of prevention strategies, development of human resources, promotion of clinical trial infrastructure and investment in new technologies must be placed as a priority to permit advancements in innovation and equitable cancer care. - Some of the metrics are blocked by yourconsent settings
Publication A Systematic Literature Review on the Use of Clays for Arsenic Removal(MDPI AG, 2025-05-07) ;Lorenzo Reyes-Bozo ;Eduardo Vyhmeister ;Gabriel G. Castane ;Juan Chirinos ;Jeannette Zárraga ;Claudia Sandoval-YáñezArsenic contamination in water remains a critical global challenge, particularly in rural and resource-limited regions. Clays have been widely studied as cost-effective and efficient adsorbents for arsenic removal. This systematic review provides a comprehensive analysis of the application of clays in arsenic adsorption, focusing on clay types, operational units, and study methodologies. The review classifies the adsorption mechanisms, highlights key factors influencing adsorption performance—such as pH, ionic strength, and surface modifications—and examines the effectiveness of various modifications. Furthermore, the study categorizes adsorption research into kinetic, iso-thermal, thermodynamic, and efficiency studies, providing insights into the state of the art and the experimental conditions that govern arsenic removal. It also discusses the scalability and practical application of clay-based adsorption technologies, emphasizing gaps in field validation, regeneration studies, and large-scale implementation. The findings highlight the potential of natural and modified clays in arsenic remediation, while underscoring the need for further research to optimize adsorption conditions and enhance sustainability in water treatment systems.